Adenovirus DNA integration into mammalian genomes, adenovirus vector DNA & RNA-based SARS-CoV-2 vaccines, adenovirus vector DNA integration into human genome, Anvisa, Bolsanaro, Brazil, Covid-19 vaccines, DNA Vaccine, epigenetic consequences of foreign DNA integration, expression of adenoviral genes in vector DNA, HEK293, inspection, Putin, Putin promotes Covid-19 vaccine exports, Putin promotes Covid-19 vaccines, retrotranscription of SARS-CoV-2 RNA into DNA, Russia, Russian threats, Russian vaccine exports, Sputnik V, Sputnik V vaccines, viral vector vaccine
Sputnik V is a DNA (viral vector) vaccine, which underwent little testing, and which uses the embryonic cell line HEK293 in its production. Furthermore, DNA vaccines are at least as risky as mRNA vaccines, and maybe more so. Putin promoted Covid-19 testing and vaccines and vaccine export, especially to Africa, during the 2021 World Economic Forum.
The estimated $30 billion made from vaccine exports is only for Sputnik V. Russia has some other vaccines, as well: “the Russian Direct Investment Fund (RDIF), together with the Gamaleya Center, which developed the Sputnik vaccine, announced that Sputnik would be sold to foreign partners at a price of at least $20 per set. As of April 2021, it was known that Sputnik V was approved for use in 60 countries with a total population of over one and a half billion people. Experts believe that manufacturers will earn more than $ 30 billion from the export of the Russian vaccine in 2 years… The conclusion from all this is simple: vaccination, which has been made almost mandatory in Russia, brings colossal income to a very specific group of people.” Read the article here: “Attendant of billions: who literally benefits from vaccination” 12 July 2021, 10:11 Economy, By Irina Mishina
“The rejection kicked off a testy exchange with the Russian developers, who threatened to sue the Brazilian agency” https://www.reuters.com/world/americas/brazil-health-regulator-technical-staff-recommend-conditions-any-approval-2021-06-04/
Translation of original rejection statement:
“Anvisa does not approve the importation of the Sputnik V vaccine
Assessment of available data so far points to flaws in the development and production of the vaccine. There is an absence or insufficiency of quality control data, safety and efficacy of the product.
Updated on 04/28/2021 11:55 am
Due to lack of consistent and reliable data, Anvisa’s Collegiate Board (Dicol) unanimously decided not to authorize the exceptional import of the Russian Sputnik V vaccine. The request was evaluated this Monday (26/4), therefore within of the 30-day period established by the Federal Supreme Court (STF), in a decision handed down by Minister Ricardo Lewandowski.
The decision was made based on data collected and evaluated by the technical teams of the general management of Medicines and Biological Products (GGMED), of Inspection and Sanitary Inspection (GGFIS) and of Monitoring of Products Subject to Sanitary Surveillance (GGMON). The General Management of Ports, Airports and Customs Areas (GGPAF) and the Office of International Affairs (Ainte) also participated in the collection of information.
According to the rapporteur of the case, director Alex Machado Campos, the decision is a portrait of the moment. He highlighted that the Agency is known for providing access to medicines and vaccines and that, at this time of a pandemic, the institution has acted on the limit, but that there is no flexibility in relation to the safety of the products.
The rapporteur also stated that Anvisa’s daily challenge is to establish whether the benefits of vaccines outweigh the risks related to the product. “Safety is an inalienable aspect in the face of risk uncertainty. We got here hand in hand with science and supported by evidence”, said the director.
In its analysis, GGMON reinforced aspects pointed out by GGMED, but drew special attention to the issue of lack of knowledge of short, medium and long-term adverse effects resulting from the use of the vaccine.
The Enforcement area also detected a number of issues related to the Sputnik V vaccine, including as a result of an inspection mission sent to Russia. According to the GGFIS, the lack of a technical report on the approval of the product resulted in the need for an on-site inspection to allow the assessment of the manufacturing conditions of the companies involved in the production of the biological pharmaceutical ingredient and the vaccine.
During the visit, no manufacturing conditions were identified that demonstrate that the products are consistently manufactured and controlled, resulting in a product with the required quality for its intended use. GGFIS also reported that, on Russian soil, the inspection team was denied access to the facilities of Gamaleya, the institute that developed the vaccine.
According to director Meiruze Freitas, society expects Anvisa’s speed and responsibility in the approval that guarantees the quality, safety and efficacy of medicines and vaccines. “I sincerely express here that we are doing everything we can to ensure that vaccines for Covid-19 reach the people of this nation and that they meet the standards of quality, safety and efficacy. Every time a Brazilian or Brazilian, including members of our own family, receives a dose of the vaccine against Covid-19, when their arms are offered, they need to have confidence in the work of Anvisa’s public servants “, said the director. Meiruze Freitas also reinforced that vaccines against Covid-19 are medicines developed and produced to save human lives, so there is a requirement for consistent data about the product. “I really hope that the Sputnik V vaccine process will adapt your information and quickly resolve compliance issues, because millions of people need access to safe and effective vaccines,” she concluded.
Director Cristiane Rose Jourdan Gomes reinforced that the analysis carried out by the technical team does not seem to include the minimum of sufficient data, which contrasts with the numerous existing uncertainties. “In fact, this is a delicate issue, as the availability of yet another vaccine, as long as it is approved by Anvisa, is a priority to compose a range of immunizing agents to combat Covid-19. As an optimist, I hope that, in the shortest possible time, the lack of information from Sputnik V will be overcome”, said Cristiane.
In his speech, CEO Antonio Barra Torres insisted on reinforcing that the institution is respected nationally and internationally and that it will not abdicate its mission. He pointed out that the Agency has already authorized five vaccines, two of them in record time in the world. “But also, within the scope of our competence, we will never allow, without the necessary evidence, that millions of Brazilians are exposed to products without due proof of their quality, safety and efficacy or, at the very least, in the face of the serious situation we go through, a favorable risk-benefit relationship”.
The assessment of the exceptional import request for the Sputnik V vaccine was based on Law 14.124/2021, which determined that entities that request authorization for emergency and temporary use of vaccines against Covid-19 must submit a series of information to Anvisa. Among the requirements is the technical evaluation report, issued by certain international health authorities, capable of proving that the vaccine meets pre-established quality, efficacy and safety standards. In the absence of the technical report, the Agency’s decision period is up to 30 days. The evaluation also follows the rules of the Collegiate Board Resolution (RDC) 476/2021.
Therefore, for director Romison Rodrigues Mota, Law 14.124/2021, which enables and brought into the legal framework the figure of exceptional importation, recognizes the Agency’s competence to evaluate requests of this nature. “We cannot give up our responsibility, the competence of Anvisa to act on issues related to health surveillance, which is the objective of the institution to exist”. See original here: https://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2021/anvisa-nao-aprova-importacao-da-vacina-sputnik-v
“Sputnik V COVID-19 vaccine – statistics & facts”
Published by Statista Research Department, Nov 5, 2021
“The currently administered vaccines depend on adenovirus DNA vectors or on SARS-CoV-2 mRNA that might become reverse transcribed into DNA, however infrequently. In some societies, people have become sensitized against the potential short- or long-term side effects of foreign DNA being injected into humans. In my laboratory, the fate of foreign DNA in mammalian (human) cells and organisms has been investigated for many years. In this review, a summary of the results obtained will be presented. This synopsis has been put in the evolutionary context of retrotransposon insertions into pre-human genomes millions of years ago. In addition, studies on adenovirus vector-based DNA, on the fate of food-ingested DNA as well as the long-term persistence of SARS-CoV-2 RNA/DNA will be described. Actual integration of viral DNA molecules and of adenovirus vector DNA will likely be chance events whose frequency and epigenetic consequences cannot with certainty be assessed. The review also addresses problems of remaining adenoviral gene expression in adenoviral-based vectors and their role in side effects of vaccines. Eventually, it will come down to weighing the possible risks of genomic insertions of vaccine-associated foreign DNA and unknown levels of vector-carried adenoviral gene expression versus protection against the dangers of Covid-19.… Informing the public about the complexities of biology will be a reliable guide when having to reach personal decisions about vaccinations.
Keywords: Adenovirus DNA integration into mammalian genomes, adenovirus vector DNA integration into human genome, expression of adenoviral genes in vector DNA, adenovirus vector DNA & RNA-based SARS-CoV-2 vaccines, epigenetic consequences of foreign DNA integration, retrotranscription of SARS-CoV-2 RNA into DNA” See: Doerfler, Walter. “Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome – Are Adenoviral Genes Expressed in Vector-based Vaccines?.” Virus research vol. 302 (2021): 198466. doi:10.1016/j.virusres.2021.19846 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168329/
World Economic Forum 2021: Putin Promotes Coronavirus (Covid-19) Vaccination and Testing; Expanding it to Africa
At the 2021 World Economic Forum (WEF) Putin discussed knowing the Chair of the WEF, German Klaus Schwab, since the 1990s and attending WEF events. Putin has never hidden his friendship with Kissinger, either. Kissinger played an early role in WEF. Who do Schwab, Kissinger and Putin serve? The first two were born in Germany and Putin served alongside the German Stasi. Kissinger was responsible for opening up US-China relations and Klaus Schwab was in China very early. Germany? China?
In the following clip, Klaus Schwab discusses with Costa Rica’s President Quesada that Putin, Merkel, Tony Blair, Austrian former chancellor Kurz, the New Zealand Prime Minister were WEF young global leaders. https://www.bitchute.com/video/ycvtBhjrheTE
Putin remarks at the World Economic Forum where he discusses being connected to Klaus Schwab since the 1990s: https://www.c-span.org/video/?508286-101/russian-president-vladimir-putins-remarks-world-economic-forum
As can be seen, c-span scrubbed it. However, the fact that it existed can be seen here:
It’s here at around 2.31 pm: https://archive.org/details/CSPAN_20210127_185600_Russian_President_Vladimir_Putin_Addresses_World_Economic_Forum/start/2100/end/2160
Also here at around 56 minutes: “LIVE: Putin addresses virtual World Economic Forum” https://youtu.be/nIwSkPL0USw
Text excerpt from the c-span video:
“Mr. Schwab, dear Klaus, Colleagues,
I have been to Davos many times, attending the events organized by Mr. Schwab, even back in the 1990s. Klaus just recalled that we met in 1992. Indeed, during my time in St Petersburg, I visited this important forum many times. I would like to thank you for this opportunity today to convey my point of view to the expert community that gathers at this world-renowned platform thanks to the efforts of Mr. Schwab…
“At the same time there are certainly problems that concern every state without exception. One example is cooperation in studying and countering the coronavirus infection. As you know, several strains of this dangerous virus have emerged. The international community must create conditions for cooperation between scientists and other specialists to understand how and why coronavirus mutations occur, as well as the difference between the various strains.
Of course, we need to coordinate the efforts of the entire world, as the UN Secretary-General suggests and as we urged recently at the G20 summit. It is essential to join and coordinate the efforts of the world in countering the spread of the virus and making the much needed vaccines more accessible.
We need to help the countries that need support, including the African nations. I am referring to expanding the scale of testing and vaccinations.
We see that mass vaccination is accessible today, primarily to people in the developed countries. Meanwhile, millions of people in the world are deprived even of the hope for this protection. In practice, such inequality could create a common threat because this is well known and has been said many times that it will drag out the epidemic and uncontrolled hotbeds will continue. The epidemic has no borders.
There are no borders for infections or pandemics. Therefore, we must learn the lessons from the current situation and suggest measures aimed at improving the monitoring of the emergence of such diseases and the development of such cases in the world.
Another important area that requires coordination, in fact, the coordination of the efforts of the entire international community, is to preserve the climate and nature of our planet. I will not say anything new in this respect…”
Putin’s and his cronies have been very connected to Klaus Schwab and WEF, though there have been attempts to scrub this association in the last few days. It’s unclear if that is due to sanctions, or hiding that Putin’s a Davos man since the 1990s: https://miningawareness.wordpress.com/2022/02/25/some-world-economic-forum-strategic-partners-will-surprise-include-russian-government-owned-controlled-companies/
“The HEK293 cell line was established by transforming human embryonic kidney cells with sheared adenovirus type 5 DNA (Graham et al., 1977). Since then, many subtypes and derivatives have been established… HEK293 is commonly used in the production of viral vectors. It is used in the production of adenoviral and adeno-associated viral vectors due to presence of the adenoviral E1A/B genes which provide helper functions during viral vector production.” Front Bioeng Biotechnol. 2021; 9: 796991. “HEK293 Cell Line as a Platform to Produce Recombinant Proteins and Viral Vectors” Tan, Chin, Lim and Ng. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711270/
“Attendant of billions: who literally benefits from vaccination“
12 July 2021, 10:11 Economy, By Irina Mishina
“Vaccination in Russia is in full swing. What did not succeed through persuasion was achieved with the help of tough measures, up to and including the denial to work….
It is also worth noting that the Russian Direct Investment Fund (RDIF), together with the Gamaleya Center, which developed the Sputnik vaccine, announced that Sputnik would be sold to foreign partners at a price of at least $20 per set. As of April 2021, it was known that Sputnik V was approved for use in 60 countries with a total population of over one and a half billion people. Experts believe that manufacturers will earn more than $ 30 billion from the export of the Russian vaccine in 2 years…
The conclusion from all this is simple: vaccination, which has been made almost mandatory in Russia, brings colossal income to a very specific group of people…” Read the article here. https://web.archive.org/web/20220312053244/https://en.newizv.ru/news/economy/12-07-2021/satellite-of-billions-who-literally-benefits-from-vaccination
Those among the anti-vaccine folks, who morphed into Russian apologists after Russia invaded Ukraine, didn’t discuss any of this.
The Sputnik vaccine is supposed to have been developed and, in part, produced by a Russian government institution. If true, then the vaccine export profits could be funding the war in Ukraine. That would explain why those sowing distrust in western vaccines suddenly flipped to supporting Russia’s invasion of Ukraine. Foreign vaccines are business competitors. Brazil is using a Chinese vaccine, as well as others. Brazil was alarmed about finding living cold viruses in the Sputnik vaccine vials. Nonetheless, the government was intimidated into approving Sputnik. Both Bolsonaro and Lula have had good relations with Putin.
“Brazil report: Russian Sputnik vaccine carried live cold virus” AFP, Apr 29 2021 https://news.abs-cbn.com/overseas/04/29/21/brazil-covid19-sputnik-vaccine
Reading the following article brings many questions to mind. One is if Russia even developed a vaccine or is buying a vaccine from another party? Are they importing a foreign vaccine for use within Russia and exporting another? Or perhaps this is contracts to manufacture the vaccine in India or elsewhere? “Gunzburg and the center of Gamaleya: from whom do they buy the vaccine in bulk for rubles and dollars?” November 1, 2021, By Anastasia Stepanova https://web.archive.org/web/20220611190244/https://regnum.ru/news/economy/3412179.html
An educated guess, based on available information, is that Russia stole the viral vector technology from the UK and/or that they imported vaccines for use by high ranking officials, and rich Russians, and tried to reverse engineer it. The general public and foreign countries were the guinea pigs for the reverse engineered versions. This saved them R&D costs. These are educated hunches, based on over a decade of intermittent research of Putin’s regime, the USSR, and the earlier Russian Empire.