academic funding, Conflict of Interest, coronaviruses, Covid vaccines, COVID-19, DNA, Endogenous retroviruses, Houston Methodist Research Institute, human genome, informed consent, Malgorzata Kloc, MD Anderson, Moderna, mRNA, mRNA vaccines, Novartis, Novartis funded research, Pfizer, placenta, placenta spike protein, Rafik Ghobrial, Research conflict of interest, research funding, retroviruses, RNA, SARS-CoV-2, spike protein, syncytin, Texas, Vaccination, Vaccine hesitancy, vaccine pregnancy research
Novartis is involved in helping produce Pfizer mRNA vaccines and working on a new mRNA vaccine by CureVac (Reuters, 21 July 21: https://archive.md/bjDNW )
Two Novartis supported authors wrote a paper (Kloc, Malgorzata et al., 19 March 2021) dismissing concerns about similarities between Human syncytin-1, which is of retroviral origin, and which “plays a role in human placentation” and “the spike protein expressed on the surface of SARS-CoV-2”. (Kloc, Malgorzata et al., 2021) Of the four authors, Malgorzata Kloc,and Rafik M. Ghobrial received funding from Novartis. The concern is that training your body to attack the spike protein in the vaccine could result in the body attacking the placenta, meaning that the person cannot have a baby.
This is a serious topic, which should be independently addressed and not by Novartis-funded researchers. No one can trust researchers who are funded by those who have financial interests. And, one cannot speak of “informed consent” for vaccinations, when the researchers have financial interests-appear to be hired hacks.
Bolze PA, Mommert M, Mallet F. “Contribution of Syncytins and Other Endogenous Retroviral Envelopes to Human Placenta Pathologies. Prog Mol Biol Transl Sci. 2017;145:111-162. doi: 10.1016/bs.pmbts.2016.12.005. Epub 2017 Jan 16. PMID: 28110749.
The impacts are apparently not limited to the placenta, as reported in “Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality” by Thiago Souza et al., 2021, Oswaldo Cruz Foundation DOI: 10.21203/rs.3.rs-514541/v1 And, elsewhere: “Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients”, by Emanuela Balestrieri et al., 2021 https://doi.org/10.1016/j.ebiom.2021.103341
By Novartis funded Malgorzata Kloc’s own admission, Syncytin-1 “is slightly similar to the spike protein expressed on the surface of SARS-CoV-2”. However, Kloc, Malgorzata et al. conclude that “It is very unlikely that any spike protein-specific SARS-CoV-2 vaccine would generate an immune response which is cross-reactive with syncytin 1 and affect fertility and pregnancy.” (Kloc, Malgorzata et al., Mar 2021) They don’t say impossible but “very unlikely”. They also admit some similarity between Syncytin-1 and SARS-CoV-2.
Additionally, they admit that “Further evaluation of potential impacts of COVID-19 vaccines on fertility, placentation, pregnancy and general health of mother and newborn is required.”(Kloc, Malgorzata et al., Mar 2021)
Apparently due to Novartis funding, Kloc, Malgorzata et al., (Mar 2021) went to extremes with their polemical title, calling the concerns a “Disturbing Narrative”.
What is disturbing is that the affiliation listed on the top of the paper for the two Novartis-funded authors sounds like they should be objective (Houston Methodist and MD Anderson), and it is only at the bottom that one reads: “We thank The William Stamps Farish Fund and Novartis for support of MK and RMG”: Malgorzata Kloc,1,2,3,* and Rafik M. Ghobrial1,2, affiliation is listed as 1Houston Methodist Research Institute, Houston, TX 77030, USA; 2Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, USA and 3MD Anderson Cancer Center, Department of Genetics, University of Texas, Houston, TX 77030, USA.
Furthermore, Kloc, Malgorzata et al. claim that “This research received no external funding”, which is misleading at the very least and appears false. Additionally, “The authors declare no conflict of interest,” which appears even more misleading. It appears false.
The complete citation is Kloc, Malgorzata et al. “Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 Vaccination.” Biology vol. 10,3 238. 19 Mar. 2021, doi:10.3390/biology1003023 Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
The four authors are Malgorzata Kloc,Ahmed Uosef,Jacek Z. Kubiak, Rafik M. Ghobrial
Covid-19 is a coronavirus, which is an RNA virus. Viruses are not living, but are packets of DNA or RNA. Viruses act as parasites, which hijack the host cell. Thus, the so-called mRNA vaccines, which packets genetic material, appear to be man-made viruses, or arguably so. Both Coronaviruses and Retroviruses are packets of RNA, rather than DNA. However, the mechanism of replication is supposed to be different. A “retrovirus is a type of virus that inserts a copy of its RNA genome[a] into the DNA of a host cell that it invades, thus changing the genome of that cell.”https://en.wikipedia.org/wiki/Retrovirus
The apparent purpose of the vaccine is to inject mRNA, in order for your body to make a spike virus fragment, and then your immune system learns to attack the spike virus fragment. Coronaviruses are supposedly not taken into the nucleus and incorporated into the DNA, though new evidence shows that they sometimes are incorporated into the DNA. There have been claims that Covid-19 has incorporated an HIV backbone, which is a retrovirus. In the case of retroviruses, it is allegedly “possible to take out all of the genes that allow thretrovirus to replicate itself”. https://www.genome.gov/genetics-glossary/Retrovirus Is it possible in the context of the mRNA vaccines? And, did they really do it? How could it be deactivated if it must be active to do its “job” of training the immune system by producing corona spike proteins?
Retroviruses could come into play for either Covid-19 or the vaccine in this manner: “Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in the human and other mammalian species.… Lentiviruses can become endogenous (ERV), integrating their genome into the host germline genome, so that the virus is henceforth inherited by the host’s descendants.”https://en.wikipedia.org/wiki/Lentivirus Lentivirus can be used “to introduce a gene product into in vitro systems or animal models”. https://en.wikipedia.org/wiki/Lentivirus “Most of the lentiviral vectors presently in use are HIV-derived vectors.” https://ehs.stanford.edu/reference/lentivirus-fact-sheet
[Update note: This blog post has been somewhat rewritten-corrected and mostly rearranged. The nature of RNA viruses makes this topic difficult, and governments and Pharma companies have failed to adequately explain and expect blind obedience, instead. The internet companies do not make research easy. Based on research, long ago, into HIV and CJD, we thought that retrovirus and RNA virus were synonymous and stood in contrast to DNA viruses. Thus, we used the term retrovirus to get around the problems with typing out RNA virus into the search engine and only getting recent Covid-19 info, rather than basic research. At the time of our earlier research, CJD was believed to be a retrovirus before they developed the prion hypothesis. Recent research has suggested that Coronaviruses can sometimes incorporate into the genome, as do retroviruses. The very fact that they changed the classification of CJD from retrovirus and invented a hypothesis of a replicating protein (prion) speaks volumes about how little they know AND that they are making much of the world into human vaccine guinea pigs, without a true control group. Without a control group, it’s not science. Even in the case of HIV-AIDS they were always looking for a co-factor to explain why sometimes HIV positive people got AIDS and sometimes not. The author of this blog hates and abhors this topic and struggled to stay awake during genetics class (when far less was known) but there is almost no clear information available, especially in English. Montagnier’s full interviews are worthwhile in French. They return to basics. We have been trying to find information to share due to government threats of forced vaccination, so that people can make informed decisions.]
Covid-19 is a coronavirus, which is an RNA virus. It is made up of RNA, as are retroviruses. However, the mechanism of replication is supposed to be different. A “retrovirus is a type of virus that inserts a copy of its RNA genome[a] into the DNA of a host cell that it invades, thus changing the genome of that cell.”https://en.wikipedia.org/wiki/Retrovirus The apparent purpose of the vaccine is to inject mRNA, in order for your body to make a spike virus fragment, and then your immune system learns to attack the spike virus fragment. Coronaviruses are supposedly not taken into the nucleus and hence supposedly not incorporated into the DNA, though new evidence shows that they sometimes are incorporated. There have been claims that Covid-19 has incorporated an HIV backbone, which is a retrovirus.
“A retrovirus is a type of virus that inserts a copy of its RNA genome[a] into the DNA of a host cell that it invades, thus changing the genome of that cell. Once inside the host cell’s cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus. The host cell then treats the viral DNA as part of its own genome, transcribing and translating the viral genes along with the cell’s own genes, producing the proteins required to assemble new copies of the virus…”https://en.wikipedia.org/wiki/Retrovirus
8% of the human genome is comprised of “Retrovirus-like elements”: “Exogenous retroviruses seem to have arisen from endogenous retrotransposons by acquisition of a cellular envelope gene (env)147. Transposition occurs through the retroviral mechanism with reverse transcription occurring in a cytoplasmic virus-like particle, primed by a tRNA (in contrast to the nuclear location and chromosomal priming of LINEs). Although a variety of LTR retro-transposons exist, only the vertebrate-specific endogenous retro-viruses (ERVs) appear to have been active in the mammalian genome. Mammalian retroviruses fall into three classes (I±III), each comprising many families with independent origins. Most (85%) of the LTR retroposon-derived `fossils’ consist only of an isolated LTR, with the internal sequence having been lost by homologous recombination between the flanking LTRs.” See: “Initial sequencing and analysis of the human genome”, p.880, NATURE, VOL 409, 15 FEBRUARY 2001 https://www.genome.gov/Pages/Newsroom/Webcasts/2010ScienceReportersWorkshop/Panel1_InitalSequencing_and_Analysis_%20of_the_Human_Genome.pdf
An amazing article: Haig D. “Retroviruses and the placenta”. Curr Biol. 2012 Aug 7;22(15):R609-13. doi: 10.1016/j.cub.2012.06.002. PMID: 22877784 https://haiggroup.oeb.harvard.edu/files/haig/files/1-s2.0-s0960982212006410-main.pdf