animal models, antibodies, Clinical trials, coronavirus vaccine, COVID-19, Covid-19 antibodies, cowpox, GSK, immune responses, immunopathologic reaction, MERS, pulmonary disease, RSV, safe vaccines, SARS, SARS CoV, SARS vaccines, SARS-CoV-2, scientific rigor, smallpox, social distancing, Trump Administration, vaccine, vaccine safety concerns
Extensive research was done seeking a vaccine for SARS-CoV (SARS Coronavirus). We are now on SARS-CoV-2. They reportedly opted to not call it SARS-2 so as not to scare people. But, they should have scared people, and then perhaps it would have been taken more seriously, and not been allowed to spread. Vaccines have saved lives. But, they can and have created illness/made diseases worse, as explained further below. Americans, especially, need to beware with an on-the-make, untrustworthy President and administration. A Covid-19 vaccine – especially a fast-tracked one – could be dangerous. Thus, we volunteer the armed Michigan protesters for the first shots, along with the “challenge” of Covid-19 exposure. They can be the primate guinea pigs. Then they may get holes in their lungs to go with holes in their heads and hearts. If you want to protest, call and write your officials. The best way to avoid Covid-19 remains social distancing – as far away from people as you can get, which depends on your circumstances. And, for people to have good manners and good hygiene. However, you can’t control other people, which is why avoidance is safest, when feasible. The human species did not evolve in large groups. Cities-crowds were always centers of infection. The most idiotic of all are those protesting vaccinations all while in a crowded protest, which will further spread Covid-19. They are pushing us toward a future where there may, indeed, be forced vaccination with a rushed, potentially unsafe, vaccine. Either they are pure idiots, or paid protesters.
In the 1960s, in clinical trials, children who were vaccinated against RSV “experienced exacerbated pulmonary disease and the majority required hospitalization upon subsequent wild-type RSV infection. Two fatalities occurred in the group of vaccinated children that were attributed to the vaccine. Children from the control group that did not receive the RSV vaccine experienced significantly milder symptoms” (Patricia Kaaijk,et al., 2013)
Trump will idiotically say “what have you got to lose”, and maybe already has. But, there is apparently a lot to lose if you are given a bad vaccine.
This was written in 2012. We hope that advances have been made, over the last eight years, while remaining skeptical. However, an article from May 4, 2020 still warns to beware the risks of unvetted vaccines in general, and this topic, in particular “This combined experience provides concern for trials with SARS-CoV vaccines in humans. Clinical trials with SARS coronavirus vaccines have been conducted and reported to induce antibody responses and to be “safe” [29,30]. However, the evidence for safety is for a short period of observation. The concern arising from the present report is for an immunopathologic reaction occurring among vaccinated individuals on exposure to infectious SARS-CoV, the basis for developing a vaccine for SARS. Additional safety concerns relate to effectiveness and safety against antigenic variants of SARS-CoV and for safety of vaccinated persons exposed to other coronaviruses…” The abstract conclusion is: “Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated“. (Tseng et al., 2012 – See article below) IN SHORT, THE VACCINE MAY APPEAR SAFE UNTIL YOU ARE EXPOSED TO THE VIRUS OR RELATED VIRUSES.
In “Balancing Expediency and Scientific Rigor in SARS-CoV-2 Vaccine Development” Kevin W. Graepel, PhD, MD et al. (2020) the authors point out that the COVID-19 pandemic has led to numerous “potential vaccine candidates and calls for their rapid and widespread deployment, prompting discussions about the risks of advancing unvetted vaccines into the general population…” and concerns about “whether vaccine-elicited immune responses will protect without causing harm.” They state that those who survived the related coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV) developed antibodies for one to three years. Furthermore, they note that “the mechanisms underlying the immunopathology of coronavirus vaccines and the differences among vaccine candidates and animal models remain poorly understood. Potential factors include the vaccine itself, the viral strain used for challenge, the animal model, and the timing and dose of both vaccine and challenge. Identifying the basis for immunopathology will be important for optimizing vaccine candidates.” Read the article here: Kevin W Graepel, PhD, MD, Sonali Kochhar, MD, Ellen W Clayton, MD, JD, Kathryn E Edwards, MD, “Balancing Expediency and Scientific Rigor in SARS-CoV-2 Vaccine Development“, The Journal of Infectious Diseases, jiaa234, 04 May 2020: https://doi.org/10.1093/infdis/jiaa234
If the antibodies only last one to three years, as stated above, then whoever develops a vaccine will make a killing, one way or another.
Smallpox vaccine seems to have been a more natural way of doing things. It is a weaker, related, virus, which you probably learned about in school. “The smallpox vaccine protects people from smallpox by helping their bodies develop immunity to smallpox. The vaccine is made from a virus called vaccinia, which is a poxvirus similar to smallpox, but less harmful“. https://www.cdc.gov/smallpox/vaccine-basics/index.html https://en.wikipedia.org/wiki/Cowpox
“Correction: Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus” by Chien-Te Tseng, Elena Sbrana, […], and Robert B. Couch “There were errors in Figures 1, 2, and 4. The correct figures can be viewed here“: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436093/?report=reader
In other words, immunization with SARS Coronavirus vaccine led to lung disease when individuals were subsequently exposed to the SARS coronavirus! Notice that the only one discussed that appears safe (GSK) uses hamsters, whereas most used mice. So, we don’t know if the difference is because of the vaccine or because of the hamsters! Related: https://miningawareness.wordpress.com/2020/03/14/uk-chief-sci-advisor-former-gsk-pharma-exec-wants-to-let-coronavirus-spread-for-herd-immunity/
“In these clinical trials, vaccinated RSV naïve children experienced exacerbated pulmonary disease and the majority required hospitalization upon subsequent wild-type RSV infection. Two fatalities occurred in the group of vaccinated children that were attributed to the vaccine. Children from the control group that did not receive the RSV vaccine experienced significantly milder symptoms”
See: “Vaccination against RSV Is maternal vaccination a good alternative to other approaches?” By Patricia Kaaijk,* Willem Luytjes and Nynke Y. Rots Centre for infectious Diseases Control; National Institute for Public Health and the Environment (RIVM); Bilthoven, the Netherlands Human Vaccines & Immunotherapeutics 9:6, 1263–1267; June 2013; © 2013 Landes Bioscience https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901815/ (In this context, naive means not previously exposed.)
Some notes from the Kevin W. Graepel, PhD, MD et al. (2020) article:
7. “Consensus considerations on the assessment of the risk of disease enhancement with COVID-19 vaccines” [Internet]. 2020 Apr pp. 1–5. Available from:
8. Iwata-Yoshikawa N, Uda A, Suzuki T, et al. “Effects of Toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine“. Perlman S, editor. J Virol. American Society for Microbiology Journals; 2014; 88(15):8597–8614.