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It appears best and safest to give directly to the official Navajo Nation Covid-19 Relief Fund through their governmental web site. They take monetary and non-monetary donations. Donations are tax deductible. Some other fundraising activities may or may not be legitimate, and may take a percentage.

Click on the Donate button on this Navajo Nation Governmental (Dept. of Health) web site to donate: https://www.ndoh.navajo-nsn.gov/COVID-19

At the Donate Button linked page it explains:
Navajo Nation COVID-19 Relief Fund
The Navajo Nation COVID-19 Fund has been established to help the Navajo Nation respond to the COVID-19 pandemic. This is the Navajo Nation’s only official COVID-19 fundraising and donation effort.

The Navajo Nation is accepting monetary and non-monetary donations to address immediate medical and community needs. Charitable donations to the Navajo Nation are deductible by the donor for federal income, estate, and gift tax purposes” Read more here, including lists of their medical and community needs: https://www.nndoh.org/donate.html

As of April 24th: “After New York and New Jersey, the place with the highest coronavirus infection rate in the U.S. is the Navajo Nation.” Furthermore, “Other long-standing problems have contributed to the rapid spread of the disease on the Navajo Nation. Many households lack clean, running water, which makes frequent hand-washing difficult. Some homes do not have reliable electricity. And hospitals are few and far apart for a reservation the size of West Virginia.” See: https://www.npr.org/2020/04/24/842945050/navajo-nation-sees-high-rate-of-covid-19-and-contact-tracing-is-a-challenge

The Navajo Nation (Navajo: Naabeehó Bináhásdzo) is an Native American[2] territory covering about 17,544,500 acres (71,000 km2; 27,413 sq mi), occupying portions of northeastern Arizona, southeastern Utah, and northwestern New Mexico in the United States. This is the largest land area retained by an indigenous tribe in the United States, with a population of roughly 350,000 as of 2016.

By area, the Navajo Nation is larger than ten U.S. states – West Virginia, Maryland, Hawaii, Massachusetts, Vermont, New Hampshire, New Jersey, Connecticut, Delaware and Rhode Island – and is less than one percent shy of being equal to the combined area of the last five (New Hampshire through Rhode Island).

Navajo Nation, hit hard by COVID-19, comes together to protect its most vulnerable:

Link: https://youtu.be/7jh55Zpml4o